Phenotypes Associated with This Genotype

Genotype
MGI:5661487

• Allelic Composition: Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0; Tg(LCKprBCL2)36Sjk/0
• Genetic Background: involves: C57BL/6 * C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by the F5 TCR-specific peptide NP, indicating impaired clonal deletion

hematopoietic system

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

abnormal T cell clonal deletion ( J:217939 )

• thymocytes are protected from apoptosis induced by the F5 TCR-specific peptide NP, indicating impaired clonal deletion

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis

cellular

decreased thymocyte apoptosis ( J:217939 )

• thymocyte apoptosis is inhibited in response to injection with the F5 TCR-specific peptide NP compared to controls which show massive apoptosis