Phenotypes Associated with This Genotype

Genotype
MGI:5661485

• Allelic Composition: Tg(LCKprBCL2)36Sjk/0
• Genetic Background: B6.Cg-Tg(LCKprBCL2)36Sjk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell subpopulation ratio ( J:217939 )

• the CD4 to CD8 T cell ratio is somewhat skewed in favor of CD8 T cells

abnormal CD4-positive, alpha-beta T cell number ( J:217939 )

• mice show a higher proportion of previously activated, anergic CD4 T cells

increased regulatory T cell number ( J:217939 )

• greater Foxp3+ Treg cell proportions and numbers in both the thymus and lymph nodes

immune system

abnormal T cell subpopulation ratio ( J:217939 )

• the CD4 to CD8 T cell ratio is somewhat skewed in favor of CD8 T cells

abnormal CD4-positive, alpha-beta T cell number ( J:217939 )

• mice show a higher proportion of previously activated, anergic CD4 T cells

increased regulatory T cell number ( J:217939 )

• greater Foxp3+ Treg cell proportions and numbers in both the thymus and lymph nodes