Phenotypes Associated with This Genotype

Genotype
MGI:5661382

• Allelic Composition: Fgf8^tm1Moon/Fgf8^tm1Moon; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

aberrant origin of the right subclavian artery ( J:170879 )

right aortic arch ( J:170879 )

abnormal common carotid artery morphology ( J:170879 )

• absence of the left common carotid artery in some mice

abnormal cardiovascular development ( J:170879 )

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac epithelial to mesenchymal transition ( J:170879 )

• impaired at E10.5

abnormal cardiac outflow tract development ( J:170879 )

• hypomorphic at E9.5

double outlet right ventricle ( J:170879 )

ventricular septal defect ( J:170879 )

decreased heart right ventricle size ( J:170879 )

• hypomorphic at E9.5

craniofacial

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

cellular

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5

embryo

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5