Phenotypes Associated with This Genotype

Genotype
MGI:5661333

• Allelic Composition: \Ccr7^tm1Rfor/\Ccr7^tm1Rfor
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal dendritic cell chemotaxis ( J:223508 )

• very few CD103+ and CD11b^hi dendritic cells migrate to the mediastinal lymph nodes in both steady state conditions and following OVA/LPS instillation

hematopoietic system

abnormal dendritic cell chemotaxis ( J:223508 )

• very few CD103+ and CD11b^hi dendritic cells migrate to the mediastinal lymph nodes in both steady state conditions and following OVA/LPS instillation

decreased CD103-positive CD11b-low dendritic cell number ( J:223508 )

• CD103+ dendritic cells are almost absent in the mediastinal lymph nodes in both steady state conditions and following OVA/LPS instillation

decreased CD11b-high dendritic cell number ( J:223508 )

• some CD11b^hi dendritic cells are present in the mediastinal lymph nodes in both steady state conditions and following OVA/LPS inhalation, but are fewer in number than wild-type

immune system

abnormal dendritic cell chemotaxis ( J:223508 )

• very few CD103+ and CD11b^hi dendritic cells migrate to the mediastinal lymph nodes in both steady state conditions and following OVA/LPS instillation

decreased CD103-positive CD11b-low dendritic cell number ( J:223508 )

• CD103+ dendritic cells are almost absent in the mediastinal lymph nodes in both steady state conditions and following OVA/LPS instillation

decreased CD11b-high dendritic cell number ( J:223508 )

• some CD11b^hi dendritic cells are present in the mediastinal lymph nodes in both steady state conditions and following OVA/LPS inhalation, but are fewer in number than wild-type