Analysis Tools
nervous system
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• mice show a reduction of synaptic inhibition onto D1-dopamine receptor-expressing medium spiny neurons of the nucleus accumbens, with the miniature inhibitory postsynaptic current (mIPSC) frequency in the nucleus accumbens reduced by about 50%, whereas the mIPSC amplitude is unchanged
• however, no change in mIPSC frequency or amplitude is seen in D2-dopamine receptor-expressing medium spiny neurons and no change is seen in mIPSC frequency or amplitude in D1-dopamine receptor-expressing medium spiny neurons of the dorsal striatum
• spontaneous miniature excitatory postsynaptic currents (mEPSCs) from medium spiny neurons are normal, no changes in paired-pulse ratio of evoked EPSCs, and function of group I metabotropic glutamate receptors in medium spiny neurons of the nucleus acumbens is not altered
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