Phenotypes Associated with This Genotype

Genotype
MGI:5659906

• Allelic Composition: Arhgap26^{Gt(OST135790)Lex}/Arhgap26^{Gt(OST135790)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal myoblast fusion ( J:215392 )

• in culture, hindlimb myoblasts show a reduced fusion index

decreased skeletal muscle fiber size ( J:215392 )

• relative lack of large myofibers and more small myofibers in the diaphragm and gastrocnemius muscles resulting in a decrease in mean fiber size

impaired skeletal muscle regeneration ( J:215392 )

• at 14 days post cardiotoxin-induced injury, a significant reduction in the average number of nuclei is seen in regenerating myofibers

• at 28 days post injury, cross sectional area of regenerating myofibers is reduced

behavior/neurological

decreased grip strength ( J:215392 )

• mice show a significant reduction in grip strength relative to wild-type controls

cellular

abnormal myoblast fusion ( J:215392 )

• in culture, hindlimb myoblasts show a reduced fusion index