Phenotypes Associated with This Genotype

Genotype
MGI:5648532

• Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺; Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺; Tg(tetO-Kras*G12D)#Rdp/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:186194 )

• infrequently, mice exhibit occurrence of invasive pancreatic ductal adenocarcinoma after long latency (35-70 weeks) following doxycline treatment

increased pancreatic intraepithelial neoplasia incidence ( J:186194 )

• mice develop PanIN lesions within 2 weeks of doxycycline induction

pancreatic acinar-to-ductal metaplasia ( J:186194 )

• mice develop acinar-to-ductal metaplasia within 2 weeks of doxycycline induction

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:186194 )

• infrequently, mice exhibit occurrence of invasive pancreatic ductal adenocarcinoma after long latency (35-70 weeks) following doxycline treatment

increased pancreatic intraepithelial neoplasia incidence ( J:186194 )

• mice develop PanIN lesions within 2 weeks of doxycycline induction