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Phenotypes Associated with This Genotype
Genotype
MGI:5648532
Allelic
Composition		 Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(tetO-Kras*G12D)#Rdp/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (1095 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (29 available)
Tg(tetO-Kras*G12D)#Rdp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:186194 )
• infrequently, mice exhibit occurrence of invasive pancreatic ductal adenocarcinoma after long latency (35-70 weeks) following doxycline treatment
increased pancreatic intraepithelial neoplasia incidence ( J:186194 )
• mice develop PanIN lesions within 2 weeks of doxycycline induction
pancreatic acinar-to-ductal metaplasia ( J:186194 )
• mice develop acinar-to-ductal metaplasia within 2 weeks of doxycycline induction

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:186194 )
• infrequently, mice exhibit occurrence of invasive pancreatic ductal adenocarcinoma after long latency (35-70 weeks) following doxycline treatment
increased pancreatic intraepithelial neoplasia incidence ( J:186194 )
• mice develop PanIN lesions within 2 weeks of doxycycline induction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory