Phenotypes Associated with This Genotype

Genotype
MGI:5648379

• Allelic Composition: Sox10^gt/Sox10^gt
• Genetic Background: involves: C57BL/6 * GT/Le

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hypomyelination in Sox10^gt/Sox10^gt brains

behavior/neurological

seizures ( J:216967 )

• rare survivors are seizure-prone and die suddenly

integument

head blaze ( J:216967 )

• Background Sensitivity: mice show a white forehead blaze that is often positioned further back on the body, present as one or more stripes, or absent altogether compared to mice on the GT/Le background which show a consistent size and position of the forehead blaze

mortality/aging

premature death ( J:216967 )

• rare survivors are seizure-prone and die suddenly

nervous system

seizures ( J:216967 )

• rare survivors are seizure-prone and die suddenly

abnormal myelination ( J:216967 )

• Luxol fast blue staining is almost undetectable in brains, indicating that myelination is severely disrupted

pigmentation

head blaze ( J:216967 )

• Background Sensitivity: mice show a white forehead blaze that is often positioned further back on the body, present as one or more stripes, or absent altogether compared to mice on the GT/Le background which show a consistent size and position of the forehead blaze