Phenotypes Associated with This Genotype

Genotype
MGI:5647909

• Allelic Composition: Lmx1a^tm1Tpe/Lmx1a^tm1Tpe; Lmx1b^tm1Zfc/Lmx1b^tm1Zfc; Tg(Slc6a3-cre/ERT2)1Span/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic bouton morphology ( J:222854 )

• abnormally enlarged nerve terminals are seen in mice 4 weeks after treatment with tamoxifen at 4 weeks of age, showing fewer synaptic vesicles at active zones and an increase in the number of autophagic-lysosomal vesicles

neurodegeneration ( J:222854 )

• striatal expression of dopamine transporter (DAT) is reduced in the ventral striatum 18 months after tamoxifen treatment indicating dopaminergic neuron loss, however, no loss of TH or DAT expression in the dorsal striatum and no loss of TH+ cells are seen at this time point

homeostasis/metabolism

decreased dopamine level ( J:222854 )

• dopamine and its metabolites are diminished after tamoxifen treatment of 4 week old mice