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Phenotypes Associated with This Genotype
Genotype
MGI:5646183
Allelic
Composition		 Itpr1opt/Itpr1+
Genetic
Background		 B6C3Fe-a/a-Itpr1opt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr1opt mutation (2 available); any Itpr1 mutation (185 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased insulin secretion ( J:222913 )
• at 3 months following glucose ingestion

homeostasis/metabolism
decreased insulin secretion ( J:222913 )
• at 3 months following glucose ingestion
impaired glucose tolerance ( J:222913 )
• at 3 months following glucose ingestion

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory