Analysis Tools
neoplasm
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• spontaneous development of malignant melanoma by 200 days of age in all mice treated with tamoxifen
• tumors of tamoxifen-treated mice are relatively small, with regular ovoid shape and high levels of Ki-67 staining
• naevi are not seen above dermal malignant melanomas in tamoxifen treated mice, although small nests of melanocytes in a subepidermal location are occasionally seen
• early lesions of tamoxifen treated mice do not show evidence of tumor derivation from the upper dermis and appear to be derived from follicular or other deep dermal precursors
• majority of tumors of tamoxifen treated mice are located on the back
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• all mice treated with tamoxifen develop malignant melanoma before 150 days of age after a single neonatal UVB dose
• tamoxifen-treated mice show a diminished response of melanocyte emigration from the upper regions of hair follicles to the epidermal basal layer 3-5 days after neonatal UV radiation compared to controls
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integument
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• spontaneous development of malignant melanoma by 200 days of age in all mice treated with tamoxifen
• tumors of tamoxifen-treated mice are relatively small, with regular ovoid shape and high levels of Ki-67 staining
• naevi are not seen above dermal malignant melanomas in tamoxifen treated mice, although small nests of melanocytes in a subepidermal location are occasionally seen
• early lesions of tamoxifen treated mice do not show evidence of tumor derivation from the upper dermis and appear to be derived from follicular or other deep dermal precursors
• majority of tumors of tamoxifen treated mice are located on the back
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