Phenotypes Associated with This Genotype

Genotype
MGI:5644970

• Allelic Composition: Klf4^tm1Khk/Klf4^tm1Khk; Klf5^tm1Jaw/Klf5^tm1Jaw; Tg(Pax6-cre,GFP)1Pgr/0
• Genetic Background: involves: 129S6/SvEvTac * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

decreased cornea stroma thickness ( J:175263 )

• at 8 weeks of age, the mutant corneal stroma is thinner with relatively fewer keratocytes relative to wild-type and single Klf5 conditional knockout corneas

eyelids fail to open ( J:175263 )

• mutant eyes fail to open as late as 35 weeks after birth, the latest stage examined

abnormal ocular surface morphology ( J:175263 )

• co-ablation of Klf4 and Klf5 in the ocular surface results in more severe eyelid and corneal abnormalities than those in either single conditional knockout

abnormal conjunctival epithelium morphology ( J:175263 )

• at 8 weeks of age, the mutant conjunctival epithelium is thinner than the wild-type or single Klf5 conditional knockout epithelium

absent conjunctiva goblet cells ( J:175263 )

• at 8 weeks of age, conjunctiva goblet cells are missing

abnormal cornea epithelium morphology ( J:175263 )

• at 8 weeks of age, the mutant corneal epithelium is thinner than the wild-type and single Klf5 conditional knockout corneal epithelia, and remains fused to the eyelids