Phenotypes for Isl1 Rspo3 MGI:5643693 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rspo3^tm1Arte/Rspo3^tm1Arte Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (38 available)
Rspo3^tm1Arte mutation (0 available); any Rspo3 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214093 )

• embryonic lethality at E11.5

cardiovascular system

blood vessel congestion ( J:214093 )

thin myocardium ( J:214093 )

• myocardial wall thickness is diminished at E10

abnormal cardiac outflow tract development ( J:214093 )

• poorly developed outflow tract

abnormal heart right ventricle morphology ( J:214093 )

• poorly developed right ventricle

pericardial edema ( J:214093 )

• in all mice

homeostasis/metabolism

pericardial edema ( J:214093 )

• in all mice

muscle

thin myocardium ( J:214093 )

• myocardial wall thickness is diminished at E10

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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