Phenotypes Associated with This Genotype

Genotype
MGI:5643691

• Allelic Composition: Nkx2-5^tm1Krc/Nkx2-5^tm1Krc; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214093 )

• early embryonic lethality at E10-E10.5

cardiovascular system

abnormal cardiac outflow tract development ( J:214093 )

• foreshortened outflow tract

• treatment of pregnant females from E8 to E10 with LiCl results in septation of the outflow tract in embryos, although it fails to correct the alignment defects of the outflow tract

absent heart right ventricle ( J:214093 )

• loss of right ventricle

• treatment of pregnant females from E8 to E10 with LiCl results in a larger right ventricle