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Phenotypes Associated with This Genotype
Genotype
MGI:5641375
Allelic
Composition
Chmp2bGt(XL952)Byg/Chmp2bGt(XL952)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chmp2bGt(XL952)Byg mutation (1 available); any Chmp2b mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 5 weeks of age, the total density of dendritic spines (including thin, stubby, or mushroom types) is reduced by 33% in the CA1-stratum radiatum
• a 33% drop in excitatory synapse density is observed in the CA1-stratum radiatum
• at 5 weeks of age, the total density of dendritic spines (including thin, stubby, or mushroom types) is reduced by 33% in the stratum radiatum of the hippocampal CA1 region relative to age-matched controls
• in particular, the density of mushroom spines is reduced by 50%
• at 5 weeks of age, a 33% drop in excitatory synapse density is observed in the stratum radiatum of the hippocampal CA1 region


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/16/2026
MGI 6.24
The Jackson Laboratory