Phenotypes Associated with This Genotype

Genotype
MGI:5641225

• Allelic Composition: Cd8a^m1Btlr/Cd8a^m1Btlr
• Genetic Background: C57BL/6J-Cd8a^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:221492 )

• increased frequencies of CD4+ T cells are observed among total cells or CD3+ T cells in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:221492 )

• greatly reduced frequencies of CD8+ T cells in the peripheral blood

• reduced frequencies of naive CD8+ T cells among total CD8+ T cells in the peripheral blood

• elevated frequencies of central and effector memory CD8+ T cells in the peripheral blood

• elevated mean fluorescence intensity of CD44 immunostaining on CD8+ T cells in the peripheral blood

increased susceptibility to Herpesvirales infection ( J:221492 )

• elevated MCMV titers in the spleen

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:221492 )

• increased frequencies of CD4+ T cells are observed among total cells or CD3+ T cells in the peripheral blood

abnormal CD8-positive, alpha-beta T cell differentiation ( J:221492 )

• greatly reduced frequencies of CD8+ T cells in the peripheral blood

• reduced frequencies of naive CD8+ T cells among total CD8+ T cells in the peripheral blood

• elevated frequencies of central and effector memory CD8+ T cells in the peripheral blood

• elevated mean fluorescence intensity of CD44 immunostaining on CD8+ T cells in the peripheral blood