Phenotypes Associated with This Genotype

Genotype
MGI:5638675

• Allelic Composition: App^tm3.1Tcs/App^tm3.1Tcs
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:212758 )

• mice exhibit impaired memory in the Y-maze test by 6 months of age

hematopoietic system

microgliosis ( J:212758 )

• microgliosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

homeostasis/metabolism

amyloidosis ( J:212758 )

• mice develop aggressive amyloid beta amyloidosis with age, with cortical deposition beginning at 2 months of age

• mice exhibit subcortical amyloidosis after 4 months of age

amyloid beta deposits ( J:212758 )

immune system

microgliosis ( J:212758 )

• microgliosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

nervous system

microgliosis ( J:212758 )

• microgliosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

amyloid beta deposits ( J:212758 )

astrocytosis ( J:212758 )

• astrocytosis in 9 month old mutants is greater than in 18 month old APP^tm2.1Tcs homozygotes

abnormal synapse morphology ( J:212758 )

• synaptic alternations as indicated by loss of synaptophysin and PSD95 immunoreactivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:212758