Phenotypes Associated with This Genotype

Genotype
MGI:5638110

• Allelic Composition: Tg(Tcrb-TCF3/PBX1)19Gusa/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes

neoplasm

increased leukemia incidence ( J:95693 )

• mice begin to develop leukemia at 3-4 months of age

• tumor development penetrance is 97%

• 8% of mice develop myeloid leukemia

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 4% of mice develop B-cell acute lymphoblastic leukemia

• 50% of mice develop T-cell acute lymphoblastic leukemia

• mice that develop T-cell leukemia die within 400 days; most die before the occurrence of B-cell tumors

• B and T leukemic cells infiltrate into bone marrow, spleen, thymus, lymph nodes, and frequently nonhematopoietic organs such as liver and lung

hematopoietic system

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes

immune system

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes