Phenotypes Associated with This Genotype

Genotype
MGI:5638105

• Allelic Composition: Tg(Tcrb-TCF3/PBX1)23Gusa/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes

neoplasm

increased leukemia incidence ( J:95693 )

• mice begin to develop leukemia at 3-4 months of age

• tumor development penetrance is 88%

• 4% of mice develop mixed B-cell/myeloid leukemia

• 4% of mice develop myeloid leukemia

• mice that die before 400 days of age almost all develop T-cell leukemia, while those that die at an older age develop either B-cell leukemia, myeloid leukemia, a mixed B-cell/myeloid leukemia or T-cell/myeloid leukemia

• mice show a lag period of almost 100 days between the last mouse to succumb to T-cell leukemia and the onset of B-cell or B-cell/myeloid leukemia

increased acute lymphoblastic leukemia incidence ( J:95693 )

• 13% of mice develop B-cell acute lymphoblastic leukemia

• 33% of mice develop T-cell acute lymphoblastic leukemia

• B-cell leukemia expresses B220 and lacks expression of surface IgM, suggesting pre-B-cell origin, and shows kappa light chain rearrangement

hematopoietic system

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes

immune system

decreased thymocyte number ( J:95693 )

• young mice show a 2- to 4-fold decrease in the number of thymocytes