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Phenotypes Associated with This Genotype
Genotype
MGI:5637742
Allelic
Composition
Tg(MMTV-Espl1)1Pati/0
Genetic
Background
involves: C57BL/6
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phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• high-grade mammary carcinomas with both inter- and intra-tumor heterogeneity, with features of both luminal and basal subtypes
• tumors are of high grade, solid morphology and express varying levels of estrogen receptor alpha
• multiparous mice develop mammary tumors with 80% penetrance and a median latency of 314 days
• however, no tumors are seen in nulliparous mice up to 2 years of age and nulliparous mice do not show increased Espl1 expression as is seen in multiparous mice
• four types of mammary tumors are seen; spindle-like, solid, glandular, and squamous
• mice develop regions of carcinosarcomas or epithelial-to-mesenchymal transition (EMT) tumors
• rapid tumor progression is due to increased early cellular proliferation coupled with accumulation of DNA damage

cellular
• chromosomes in transgene expressing cells are thinner
• mice progressively accumulate aneuploidy in the parous mammary epithelia and tumors show aneuploidy
• genomic instability accumulates in mammary epithelial cells of mutants before tumorigenesis
• mammary epithelial cell cultures at passage 0 from multiparous mice show an increase in micro-nuclei, multinucleated cells, chromosome bridges, and aberrant numbers of centrosomes
• mammary epithelial cells from parous mice show a 34% increase in premature sister chromatid separation

endocrine/exocrine glands
• at 6 months of age, post lactating mammary glands of females weaned on day 1 have delayed involution compared to wild-type females
• high-grade mammary carcinomas with both inter- and intra-tumor heterogeneity, with features of both luminal and basal subtypes
• tumors are of high grade, solid morphology and express varying levels of estrogen receptor alpha
• multiparous mice develop mammary tumors with 80% penetrance and a median latency of 314 days
• however, no tumors are seen in nulliparous mice up to 2 years of age and nulliparous mice do not show increased Espl1 expression as is seen in multiparous mice
• four types of mammary tumors are seen; spindle-like, solid, glandular, and squamous
• mice develop regions of carcinosarcomas or epithelial-to-mesenchymal transition (EMT) tumors
• rapid tumor progression is due to increased early cellular proliferation coupled with accumulation of DNA damage
• at 6 months of age, post lactating mammary glands of females weaned on day 1 appear severely hyperplastic
• at 12 months of age, mice develop small masses of mammary hyperplasia, large amounts of immune reaction, and presence of hyperproliferative stroma

integument
• at 6 months of age, post lactating mammary glands of females weaned on day 1 have delayed involution compared to wild-type females
• high-grade mammary carcinomas with both inter- and intra-tumor heterogeneity, with features of both luminal and basal subtypes
• tumors are of high grade, solid morphology and express varying levels of estrogen receptor alpha
• multiparous mice develop mammary tumors with 80% penetrance and a median latency of 314 days
• however, no tumors are seen in nulliparous mice up to 2 years of age and nulliparous mice do not show increased Espl1 expression as is seen in multiparous mice
• four types of mammary tumors are seen; spindle-like, solid, glandular, and squamous
• mice develop regions of carcinosarcomas or epithelial-to-mesenchymal transition (EMT) tumors
• rapid tumor progression is due to increased early cellular proliferation coupled with accumulation of DNA damage
• at 6 months of age, post lactating mammary glands of females weaned on day 1 appear severely hyperplastic
• at 12 months of age, mice develop small masses of mammary hyperplasia, large amounts of immune reaction, and presence of hyperproliferative stroma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:216267


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory