Phenotypes Associated with This Genotype

Genotype
MGI:5635846

• Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:212415 )

prenatal lethality, incomplete penetrance ( J:212415 )

renal/urinary system

renal/urinary system phenotype ( J:212415 )

N • at E16.5, mice exhibit normal kidney cell proliferation

kidney cyst ( J:212415 )

• at E16.5

abnormal glomerular capsule space morphology ( J:212415 )

• ectatic at E16.5

dilated renal tubule ( J:212415 )

• at E16.5

integument

abnormal epidermal stem cell proliferation ( J:212415 )

• at E16.5, mice exhibit reduced epidermal stem cell proliferation compared with wild-type mice

decreased hair follicle number ( J:212415 )

• at E16.5

thin epidermis ( J:212415 )

• at E16.5

abnormal skin development ( J:212415 )

• impaired

digestive/alimentary system

abnormal intestine development ( J:212415 )

• impaired embryonic gut development and intestinal stem cell compartment with loss of markers for +4 cells, goblet cells, enteroendocrine cells and enterocytes

abnormal intestine physiology ( J:212415 )

• at E16.5, crypt cell proliferation is reduced 3-fold and parts of the intestine exhibit signs of necrosis compared with wild-type mice

cellular

abnormal epidermal stem cell proliferation ( J:212415 )

• at E16.5, mice exhibit reduced epidermal stem cell proliferation compared with wild-type mice

growth/size/body

kidney cyst ( J:212415 )

• at E16.5