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Phenotypes Associated with This Genotype
Genotype
MGI:5635161
Allelic
Composition
Tg(HTT*)LXwy/0
Genetic
Background
involves: FVB/NJ
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• premature lethality around 5 months of age

behavior/neurological
• mice show sustained retroflex of head and neck indicating cervical dystonia at 4-5 months of age
• mice show chorea/dystonia-like head movements starting at 4-5 months of age

growth/size/body
• body weight loss at 5 months of age

muscle
• mice show sustained retroflex of head and neck indicating cervical dystonia at 4-5 months of age

nervous system
• mice show forebrain weight loss with modest cerebellar weight loss
• nuclear inclusions containing aggregated mutant HTT are seen in both the cortex and striatum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:219890


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory