Analysis Tools
nervous system
| N |
• mice with transgene expression induced by removal of doxycycline from the food 4-6 weeks postnatal exhibit decreased amyloid beta in the hippocampus
• mice exhibit normal synaptic plasticity and long term potentiation (LTP) is fully restored following a 6-week induction
• mice exhibit normal density of synaptophysin puncta in the stratum radiatum of the hippocampus, indicating restoration of synapse density, following a 6-week induction
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• brain weight is reduced in 6-week induced mice
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• reduction in the number of NeuN-positive cells in hippocampal area CA1 in 6-week induced mice
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astrocytosis
(
J:177847
)
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• reactive astrogliosis is seen in the cortex and hippocampus in 6-week induced mice
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behavior/neurological
| N |
• 6-week induced mice show improved associate learning in contextual fear conditioning and are indistinguishable from controls
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