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Phenotypes Associated with This Genotype
Genotype
MGI:5634918
Allelic
Composition
Bace1tm1Pcw/Bace1+
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-CDK5R1/GFP)337Lht/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Pcw mutation (1 available); any Bace1 mutation (6 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-CDK5R1/GFP)337Lht mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice with transgene expression induced by removal of doxycycline from the food 4-6 weeks postnatal exhibit decreased amyloid beta in the hippocampus
• mice exhibit normal synaptic plasticity and long term potentiation (LTP) is fully restored following a 6-week induction
• mice exhibit normal density of synaptophysin puncta in the stratum radiatum of the hippocampus, indicating restoration of synapse density, following a 6-week induction
• brain weight is reduced in 6-week induced mice
• reduction in the number of NeuN-positive cells in hippocampal area CA1 in 6-week induced mice
• reactive astrogliosis is seen in the cortex and hippocampus in 6-week induced mice

behavior/neurological
N
• 6-week induced mice show improved associate learning in contextual fear conditioning and are indistinguishable from controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory