Phenotypes Associated with This Genotype

Genotype
MGI:5634327

• Allelic Composition: St14^tm2Bug/St14^tm3Bug; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

submandibular gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the submandibular gland

decreased salivation ( J:213072 )

• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

endocrine/exocrine glands

submandibular gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the submandibular gland

decreased salivation ( J:213072 )

• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

lacrimal gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the lacrimal gland

hematopoietic system

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• the percentage of CD25+Foxp3+ cells within the CD4+ T cell population is increased in the salivary gland draining lymph nodes

increased effector memory CD4-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD4-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD4+ cells among salivary gland draining lymph node cells and splenocytes

increased effector memory CD8-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD8-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD8+ cells among salivary gland draining lymph node cells and splenocytes

decreased regulatory T cell number ( J:213072 )

• total number of Treg cells in the salivary gland draining lymph node is decreased

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• decrease in the CD4+CD25+Foxp3+ Treg cell population in spleens

homeostasis/metabolism

decreased salivation ( J:213072 )

• the salivary flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

immune system

submandibular gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the submandibular gland

lacrimal gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the lacrimal gland

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• the percentage of CD25+Foxp3+ cells within the CD4+ T cell population is increased in the salivary gland draining lymph nodes

increased effector memory CD4-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD4-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD4+ cells among salivary gland draining lymph node cells and splenocytes

increased effector memory CD8-positive, alpha-beta T cell number ( J:213072 )

• loss of CD62L (L-selectin) expression on CD4+ and CD8+ T cells from salivary gland draining lymph node and splenocytes, indicating that the majority of T cells transit to effector T cells

decreased CD8-positive, alpha-beta T cell number ( J:213072 )

• decrease in the number and percentage of CD8+ cells among salivary gland draining lymph node cells and splenocytes

decreased regulatory T cell number ( J:213072 )

• total number of Treg cells in the salivary gland draining lymph node is decreased

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:213072 )

• decrease in the CD4+CD25+Foxp3+ Treg cell population in spleens

abnormal cytokine secretion ( J:213072 )

• cytokine production is increased in local and systemic immune system

• mice exhibit an increase in IL-1beta, IL-4, IL-5, IL-, IL-10, IL-12-40, IL-13, IL-17, and IFN-gamma cytokines released from cells isolated from salivary gland salivary gland draining lymph node

• cultured splenocytes exhibit an increase in proinflammatory T/B cytokines and a decrease in the Th2 polarizing cytokine IL-4

• increase in proinflammatory cytokines is seen in the serum

abnormal chemokine secretion ( J:213072 )

• cultured splenocytes exhibit an increase in production of MCP-1, MCP-5, MIP-1beta, RANTES and MMP-9 chemokines

• increase in proinflammatory chemokines is seen in the serum

increased autoantibody level ( J:213072 )

• increase in serum levels of anti-SSA/Ro (multiple antigenic peptide (MAP)-Ro273), anti-SSB/La and anti-nuclear antibodies

increased anti-nuclear antigen antibody level ( J:213072 )

vision/eye

lacrimal gland inflammation ( J:213072 )

• increase in lymphocytic infiltration area in the lacrimal gland

decreased tear production ( J:213072 )

• tear flow rate of 24-54 week old mutants is reduced following injection of pilocarpine

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:213072