Phenotypes Associated with This Genotype

Genotype
MGI:5632159

• Allelic Composition: Cd22^m3Btlr/Cd22^m3Btlr
• Genetic Background: C57BL/6J-Cd22^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B-1a cell number ( J:220066 )

• homozygous mutant mice exhibit an increased frequency of B1a B cells in the peripheral B1 B cell compartment.

decreased B cell number ( J:220066 )

• mice homozygous for this mutation exhibit a decreased frequency of B cells in the periphery.

• homozygous mutant mice have a reduced frequency of peripheral IgM⁺ B cells.

• homozygous mutant mice have a decrease in the percentage of peripheral IgD⁺ B cells.

immune system

increased B-1a cell number ( J:220066 )

• homozygous mutant mice exhibit an increased frequency of B1a B cells in the peripheral B1 B cell compartment.

decreased B cell number ( J:220066 )

• mice homozygous for this mutation exhibit a decreased frequency of B cells in the periphery.

• homozygous mutant mice have a reduced frequency of peripheral IgM⁺ B cells.

• homozygous mutant mice have a decrease in the percentage of peripheral IgD⁺ B cells.