Phenotypes Associated with This Genotype

Genotype
MGI:5631529

• Allelic Composition: Setd5^{tm1a(EUCOMM)Wtsi}/Setd5^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Setd5^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0036_3_F05

Data Sources

IMPC Data for Setd5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

abnormal visceral yolk sac morphology ( J:261316 )

• yolk sac abnormalities

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5