Phenotypes Associated with This Genotype

Genotype
MGI:5621058

• Allelic Composition: Tg(SOD1*G85R/EYFP)641Alho/Tg(SOD1*G85R/EYFP)641Alho
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gliosis in Tg(SOD1*G85R/EYFP)641Alho/Tg(SOD1*G85R/EYFP)641Alho mice

behavior/neurological

paralysis ( J:144475 )

• mice develop lethal paralyzing motor symptoms at 9 months of age

nervous system

gliosis ( J:144475 )

• gray matter stains for GFAP in 9 month old mice, indicating a glial response

abnormal motor neuron morphology ( J:144475 )

• aggregates of mutant protein with intermediate filament proteins are seen in motor neuron cell bodies and in ventral nerve root axons

abnormal nervous system physiology ( J:144475 )

• mice develop motor neuron disease, with age of onset at 9 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 1		DOID:0060193	OMIM:105400	J:144475