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Phenotypes Associated with This Genotype
Genotype
MGI:5620602
Allelic
Composition		 Nus1tm1Wcsa/Nus1tm1.1Wcsa
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Wcsa mutation (0 available); any Nus1 mutation (16 available)
Nus1tm1Wcsa mutation (0 available); any Nus1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:215785 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit decreased cis-PTase activity in isolated membranes and mannose incorporation into proteins compared with wild-type cells
increased sensitivity to induced cell death ( J:215785 )
• in tamoxifen-treated mouse embryonic fibroblasts exposed to lovastatin
abnormal cellular cholesterol metabolism ( J:215785 )
• tamoxifen-treated mouse embryonic fibroblasts accumulate free cholesterol compared with control mice

homeostasis/metabolism
abnormal cellular cholesterol metabolism ( J:215785 )
• tamoxifen-treated mouse embryonic fibroblasts accumulate free cholesterol compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory