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Phenotypes Associated with This Genotype
Genotype
MGI:5620503
Allelic
Composition
Gnao1tm2.1Rneu/Gnao1+
Genetic
Background
B6.129S-Gnao1tm2.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2.1Rneu mutation (0 available); any Gnao1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice that survive to weaning exhibit lethality starting at around 80 days with about 50% dying by 25 weeks of age
• the 50% that survive to 25 weeks show little further premature lethality
• Background Sensitivity: premature lethality occurs after E18.5 but before 2 weeks of age on the C57BL/6J background but not on a 129S1/SvImJ background

behavior/neurological
• Background Sensitivity: mice exhibit faster sensitization to pentylenetetrazol (PTZ) kindling than controls on the C57BL/6J background but not on a 129S1/SvImJ background

nervous system
• 24-week old female mice exhibit elevated frequency of interictal epileptiform discharges, which occur more frequently during sleep than during wakefulness
• interictal epileptiform discharges frequently occur in runs of 1-3 Hz, but none meet criteria for seizures due to the short duration of discharges of less than 10 seconds
• Background Sensitivity: mice exhibit faster sensitization to pentylenetetrazol (PTZ) kindling than controls on the C57BL/6J background but not on a 129S1/SvImJ background

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
early infantile epileptic encephalopathy 17 DOID:0080450 OMIM:615473
J:216850


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory