Phenotypes Associated with This Genotype

Genotype
MGI:5620462

• Allelic Composition: Rapgef6^tm1.1Tkat/Rapgef6^tm1.1Tkat
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oligozoospermia ( J:218581 )

♂ • lower epididymal sperm concentration, with a decrease in the number of germ cells per seminiferous tubule at stage II, VII, and XI of spermatogenesis

abnormal sperm head morphology ( J:218581 )

♂ • sperm exhibit a rounder shaped head

asthenozoospermia ( J:218581 )

♂ • sperm motility rates are lower

reproductive system

asthenozoospermia ( J:218581 )

♂ • sperm motility rates are lower

abnormal seminiferous tubule morphology ( J:218581 )

♂ • enlargement of lumens in the seminiferous tubules

small testis ( J:218581 )

♂

testicular atrophy ( J:218581 )

♂

abnormal spermatogenesis ( J:218581 )

♂ • severe hypospermatogenesis

oligozoospermia ( J:218581 )

♂ • lower epididymal sperm concentration, with a decrease in the number of germ cells per seminiferous tubule at stage II, VII, and XI of spermatogenesis

abnormal sperm head morphology ( J:218581 )

♂ • sperm exhibit a rounder shaped head

reduced male fertility ( J:218581 )

♂ • successful mating rates with wild-type females and the number of fetuses resulting are lower

hematopoietic system

enlarged spleen ( J:218581 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:218581 )

♂ • enlargement of lumens in the seminiferous tubules

small testis ( J:218581 )

♂

testicular atrophy ( J:218581 )

♂

immune system

enlarged spleen ( J:218581 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:218581 )

♂N • mice exhibit normal follicle-stimulating hormone, luteinizing hormone, and testosterone serum levels

growth/size/body

enlarged spleen ( J:218581 )

♂