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Phenotypes Associated with This Genotype
Genotype
MGI:5618170
Allelic
Composition		 Slc6a3tm2(HBEGF)Rpa/Slc6a3+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a3tm2(HBEGF)Rpa mutation (0 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
loss of dopaminergic neurons ( J:215916 )
• in DT-treated mice

homeostasis/metabolism
decreased dopamine level ( J:215916 )
• mice injected intramuscularly with diphtheria toxin (DT) exhibit reduced dopamine levels in the striatum
• DT-treated mice exhibit reduced 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the striatum

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory