Analysis Tools
endocrine/exocrine glands
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• mice show a majority of atrophic microfollicles that are dispersed and detached from one another
• however, thyroid size is normal and serum-free T3 and free T4 levels are normal
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• reduction in the follicular area of the thyroid
• atrophic colloid and follicular cells
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hearing/vestibular/ear
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• mice exhibit reduced calcification of the inner ear bones at P15
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• hyperplastic changes are seen within the greater epithelial ridge
• the increased cell number in the greater epithelial ridge is followed by hypertrophic changes with enlarged cell surface
• maker analysis indicates impaired maturation of the cochlea
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• the specialized sensory epitheliums of the cochlea show greater resistance against the stretching forces of the hydrops pressure
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• structure of stereocilia bundles of the sensory cells ranges from mildly disorganized to greatly deteriorated and complete absence of the bundle
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• sensory epithelium shows massive destruction of inner and outer hair cells
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• inner hair cell degeneration gradient occurs from the base to the apex
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• outer hair cell degeneration gradient progresses from apex to base
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• the swollen tectorial membrane shows loose connective collagen bundles with an atypical basket-weave appearance
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• tectorial membrane is enlarged and thicker in all regions of the cochlea
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• hydrops of endolymphatic compartments
• organ of Corti maintains its normal width despite the tension generated by the scala media hydrops
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nervous system
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• structure of stereocilia bundles of the sensory cells ranges from mildly disorganized to greatly deteriorated and complete absence of the bundle
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• sensory epithelium shows massive destruction of inner and outer hair cells
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• inner hair cell degeneration gradient occurs from the base to the apex
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• outer hair cell degeneration gradient progresses from apex to base
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