Phenotypes Associated with This Genotype

Genotype
MGI:5617493

• Allelic Composition: Tg(Krt18-EGFP,-TAg121)36Ysng/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:189304 )

♀ • when cre-expressing adenovirus is introduced under the bursa, 72% of ovaries exhibit cytologic abnormalities in the ovarian surface epithelium

ovary hyperplasia ( J:189304 )

♀ • 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction

increased ovary tumor incidence ( J:189304 )

♀ • mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer

increased ovarian carcinoma incidence ( J:189304 )

♀ • 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa

♀ • 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

reproductive system

abnormal ovary morphology ( J:189304 )

♀ • when cre-expressing adenovirus is introduced under the bursa, 72% of ovaries exhibit cytologic abnormalities in the ovarian surface epithelium

ovary hyperplasia ( J:189304 )

♀ • 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction

increased ovary tumor incidence ( J:189304 )

♀ • mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer

increased ovarian carcinoma incidence ( J:189304 )

♀ • 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa

♀ • 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

neoplasm

increased ovary tumor incidence ( J:189304 )

♀ • mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium proliferation with progression only to stage I of ovarian cancer

increased ovarian carcinoma incidence ( J:189304 )

♀ • 27% of mice injected with cre-expressing adenovirus under the bursa develop ovarian surface epithelium carcinoma in situ with no invasion into the underlying ovary or overlying bursa

♀ • 18% of mice injected with cre-expressing adenovirus under the bursa exhibit ovarian tumors that progress to serous epithelial ovarian cancer pathology with early invasion into ovary and bursa

growth/size/body

ovary hyperplasia ( J:189304 )

♀ • 27% of mice injected with cre-expressing adenovirus under the bursa develop minimal to mild atypical hyperplasia with occasional papillary epithelial projections 3 to 24 months postinduction