Phenotypes Associated with This Genotype

Genotype
MGI:5616910

• Allelic Composition: Dgkb^{Tn(sb-lacZ,GFP)IR3.PV122Jtak}/Dgkb^{Tn(sb-lacZ,GFP)IR3.PV122Jtak}
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6N * DBA/2 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:204267 )

• methylphenidate (MPH) treatment increases the recognition index of mutants in the object-based attention test compared to wild-type mice which show decreased recognition index in response to MPH

• MPH treatment does not increase locomotor activity as in wild-type mice, except for a slight increase at 35 minutes following treatment, indicating that mutants are hyporesponsive to MPH-induced behavior change

• MPH treatment does not decrease stereotyped behaviors during short 5 minute testing as it does in wild-type mice

• MPH treatment, however, reduces the rearing behavior of mutants to levels seen in vehicle-treated wild-type mice

abnormal response to novel object ( J:204267 )

• in the object-based attention test in which mice are exposed to objects for 3 minutes during training, mutants spend less time on the novel object than wild-type mice during the retention session

• this difference is not seen when mice are exposed to the objects for 6 minutes before a retention session

• methylphenidate (MPH) treatment increases the recognition index of mutants in the object-based attention test compared to wild-type mice which show a decreased recognition index in response to MPH

increased vertical activity ( J:204267 )

• mice exhibit increased rearing behaviors in a novel environment

increased locomotor activity ( J:204267 )

• mice exhibit increased locomotor activity