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Phenotypes Associated with This Genotype
Genotype
MGI:5615728
Allelic
Composition		 Rec8mei8/Rec8mei8
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rec8mei8 mutation (1 available); any Rec8 mutation (25 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:209347 )
• spermatocytes exhibit axial element splitting in the zygotene-like stage
abnormal synaptonemal complex ( J:209347 )
• synaptonemal complex formation is largely abolished in spermatocytes

cellular
abnormal male meiosis ( J:209347 )
• spermatocytes exhibit axial element splitting in the zygotene-like stage
abnormal synaptonemal complex ( J:209347 )
• synaptonemal complex formation is largely abolished in spermatocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory