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Phenotypes Associated with This Genotype
Genotype
MGI:5615704
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chromosomal synapsis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• homolog association and pairing progress slowly in spermatocytes
abnormal male meiosis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• the initial chromosome association at the early leptotene stage is delayed in spermatocytes, indicating that homolog association and pairing progress slowly in spermatocytes

cellular
abnormal chromosomal synapsis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• homolog association and pairing progress slowly in spermatocytes
abnormal male meiosis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• the initial chromosome association at the early leptotene stage is delayed in spermatocytes, indicating that homolog association and pairing progress slowly in spermatocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory