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Phenotypes Associated with This Genotype
Genotype
MGI:5615273
Allelic
Composition
Foxh1b2b2662Clo/Foxh1b2b2662Clo
Genetic
Background
C57BL/6J-Foxh1b2b2662Clo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxh1b2b2662Clo mutation (0 available); any Foxh1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mutant exhibits displaced outflow tracts which is diagnosed as double outlet single ventricle, right aortic arch, and aberrant right subclavian artery forming incomplete vascular ring by ECM imaging

cardiovascular system

growth/size/body
• low set ears
• Complex congenital heart disease associated with heterotaxy with right isomerism.

craniofacial
• craniofacial defects including anencephaly, acrania, agnathia, microstima, microcephaly, low set ears, proboscis, cylcopia, and anophthalmia.
• low set ears

skeleton
• craniofacial defects including anencephaly, acrania, agnathia, microstima, microcephaly, low set ears, proboscis, cylcopia, and anophthalmia.
• malaligned sternal vertebra

muscle
• right side diaphragmatic hernia

respiratory system

nervous system

digestive/alimentary system
• intestinal malrotation

vision/eye

hematopoietic system

immune system

endocrine/exocrine glands

hearing/vestibular/ear
• low set ears


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory