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Phenotypes Associated with This Genotype
Genotype
MGI:5614430
Allelic
Composition		 Epha4tm1.1Bzh/Epha4tm1.2Bzh
Tg(Hoxb8-cre)1403Uze/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1.1Bzh mutation (1 available); any Epha4 mutation (67 available)
Epha4tm1.2Bzh mutation (0 available); any Epha4 mutation (67 available)
Tg(Hoxb8-cre)1403Uze mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:209606 )
• dominant hopping hindlimb gait at all frequencies of locomotion with occasional alternating gait at frequencies around and less than 4 Hz

nervous system
abnormal spinal cord morphology ( J:209606 )
• significantly wider gap between the central canal and the ventral edge of the dorsal funiculus
abnormal spinal cord dorsal column morphology ( J:209606 )
• wider and the distance from the ventral edge to the surface of the spinal cord is shorter; however, the total area is not different from controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory