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Phenotypes Associated with This Genotype
Genotype
MGI:5614091
Allelic
Composition		 Rb1tm1Tyj/Rb1+
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation (4 available); any Rb1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:215358 )
• mice develop pituitary gland tumors with a mean survival of 400 days

neoplasm
increased pituitary gland tumor incidence ( J:215358 )
• mice develop pituitary gland tumors with a mean survival of 400 days

endocrine/exocrine glands
increased pituitary gland tumor incidence ( J:215358 )
• mice develop pituitary gland tumors with a mean survival of 400 days

nervous system
increased pituitary gland tumor incidence ( J:215358 )
• mice develop pituitary gland tumors with a mean survival of 400 days

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory