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Phenotypes Associated with This Genotype
Genotype
MGI:5614076
Allelic
Composition		 Rad50tm1Jpt/Rad50tm3Jpt
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (7 available); any Gt(ROSA)26Sor mutation (1098 available)
Rad50tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:209141 )
• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system
abnormal intestine morphology ( J:209141 )
• intestinal defects are seen by day 9 of tamoxifen treatment
• die of intestinal failure

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory