Phenotypes Associated with This Genotype

Genotype
MGI:5613895

• Allelic Composition: Mex3c^tm1Aki/Mex3c^tm1Aki
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:208870 )

• approximately 1/5 of mice runts

immune system

abnormal cytokine secretion ( J:208870 )

• production of IFNB, IL6, and IL12b in peritoneal macrophages after infection with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV) but not after infection with encephalomyocarditis virus is abrogated

• production of IFNB and IL6 is also impaired after NDV or VSV infection in bone marrow derived dendritic cells or MEFs

decreased interferon-beta secretion ( J:208870 )

• by peritoneal macrophages after infection with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV) but not after infection with encephalomyocarditis virus

• production of IFNB is also impaired after NDV or VSV infection in bone marrow derived dendritic cells or MEFs

• however, production of IFNB by plasmacytoid dendritic cells after NDV or VSV infection is similar to controls

decreased interleukin-12 secretion ( J:208870 )

• by peritoneal macrophages after infection with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV) but not after infection with encephalomyocarditis virus

decreased interleukin-6 secretion ( J:208870 )

• by peritoneal macrophages after infection with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV) but not after infection with encephalomyocarditis virus

• production of IL6 is also impaired after NDV or VSV infection in bone marrow derived dendritic cells or MEFs