Phenotypes Associated with This Genotype

Genotype
MGI:5613585

• Allelic Composition: Gt(ROSA)26Sor^{tm4(Wnt7b)Flng}/Gt(ROSA)26Sor⁺; Tg(Runx2-rtTA*M2)#Flng/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal bone structure ( J:208766 )

decreased osteoclast cell number ( J:208766 )

• after doxycycline treatment

increased bone mineral density ( J:208766 )

• in the long bones after doxycycline treatment

increased trabecular bone volume ( J:208766 )

• proximal tibial trabecular bone volume/total volume is increased 6.6 fold at 2 months of age after doxycycline treatment

increased osteoblast cell number ( J:208766 )

• markedly increased after doxycycline treatment

increased trabecular bone mass ( J:208766 )

• marked increase in the trabecular bone mass in both primary and secondary ossification centers

increased bone ossification ( J:208766 )

• increased bone formation after doxycycline treatment

immune system

decreased osteoclast cell number ( J:208766 )

• after doxycycline treatment

hematopoietic system

decreased osteoclast cell number ( J:208766 )

• after doxycycline treatment