Phenotypes Associated with This Genotype

Genotype
MGI:5613584

• Allelic Composition: Gt(ROSA)26Sor^{tm4(Wnt7b)Flng}/Gt(ROSA)26Sor⁺; Tg(Col1a1-cre)1Ack/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal tibia morphology ( J:208766 )

• proximal tibial trabecular bone volume/total volume is increased 13.7 fold and 5.1 fold at 2 months and 6 months of age, respectively

• by 9 months of age bone mass of the proximal tibial trabecular area is 30% less than controls

abnormal bone structure ( J:208766 )

decreased osteoclast cell number ( J:208766 )

• osteoclast number per bone surface and percentage of bone resorption surface are reduced at 2 months of age

abnormal bone marrow cavity morphology ( J:208766 )

• absence of a marrow space in the long bones due to complete ossification

increased bone mineral density ( J:208766 )

• profoundly dense bones in both males and females throughout the body at 2 months of age

• increased density persists at 6 months of age but is partially resolved at 9 months of age

decreased trabecular bone volume ( J:208766 )

• by 9 months of age bone mass of the proximal tibial trabecular area is 30% less than controls

• however, bone mass remains increased in the distal tibia and femur at 9 months of age

increased trabecular bone volume ( J:208766 )

• proximal tibial trabecular bone volume/total volume is increased 13.7 fold and 5.1 fold at 2 months and 6 months of age, respectively

increased osteoblast cell number ( J:208766 )

• excessive osteoblasts in the presumptive marrow cavity at E18.5

• increased osteoblast number normalized to bone surface at 2 months of age

• however, the density of osteocytes is similar to controls

increased bone mass ( J:208766 )

• excessive bone occupies both primary and secondary ossification centers but the growth plate remains largely normal

• increased bone mass is seen at E18.5 and at 2 and 6 months of age

increased bone ossification ( J:208766 )

• mineral apposition rate, the percentage of mineralizing surface, and bone formation rate are all increased in the humerus

increased bone resorption ( J:208766 )

• increase in the serum levels of C-terminal telopeptide of type I collagen (a degradation product of type I collagen released upon bone resorption) at 1 and 9 months of age but not at 2 months of age

homeostasis/metabolism

increased circulating osteocalcin level ( J:208766 )

• increased at 1 and 2 months of age

increased circulating type I collagen C-terminal telopeptide level ( J:208766 )

• increase in the serum levels of C-terminal telopeptide of type I collagen (a degradation product of type I collagen released upon bone resorption) at 1 and 9 months of age but not at 2 months of age

hematopoietic system

enlarged spleen ( J:208766 )

• consistent with extramedullary hematopoiesis

increased spleen weight ( J:208766 )

decreased osteoclast cell number ( J:208766 )

• osteoclast number per bone surface and percentage of bone resorption surface are reduced at 2 months of age

immune system

enlarged spleen ( J:208766 )

• consistent with extramedullary hematopoiesis

increased spleen weight ( J:208766 )

decreased osteoclast cell number ( J:208766 )

• osteoclast number per bone surface and percentage of bone resorption surface are reduced at 2 months of age

limbs/digits/tail

abnormal tibia morphology ( J:208766 )

• proximal tibial trabecular bone volume/total volume is increased 13.7 fold and 5.1 fold at 2 months and 6 months of age, respectively

• by 9 months of age bone mass of the proximal tibial trabecular area is 30% less than controls

growth/size/body

enlarged spleen ( J:208766 )

• consistent with extramedullary hematopoiesis

increased spleen weight ( J:208766 )