Phenotypes Associated with This Genotype

Genotype
MGI:5613581

• Allelic Composition: Gt(ROSA)26Sor^{tm4(Wnt7b)Flng}/Gt(ROSA)26Sor⁺; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone morphology ( J:208766 )

• at E16.5 display a much thicker bone collar and no bone marrow

decreased length of long bones ( J:208766 )

abnormal bone structure ( J:208766 )

abnormal bone marrow cavity morphology ( J:208766 )

• at E16.5 the marrow region is occupied by cells that appear to be preosteoblasts and no marrow cavity is formed

• at E18.5 the marrow region is populated by mature osteoblasts

increased bone mineral density ( J:208766 )

• profoundly dense bones throughout the body at 2 months of age

increased osteoblast cell number ( J:208766 )

• at E18.5 the marrow region is populated by mature osteoblasts

increased bone mass ( J:208766 )

• at E18.5 and 2 months of age

• when cre expression is suppressed by doxycycline treatment until 1 month of age mice show a profound high bone mass phenotype at 2 months of age

delayed chondrocyte differentiation ( J:208766 )

• slight delay in chondrocyte maturation at E14.5