Analysis Tools
reproductive system
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• at 17-21 months of age many of the large antral follicles contain unhealthy looking irregular shaped oocytes
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• at 20 months of age ovaries contain follicles at various developmental stages and corpora lutea, unlike wild-type females that lack follicles by this age
• many of the aged ovaries display preovulatory-like follicles that are not seen in age-matched wild-type females
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• about 2 fold higher at 15 months of age
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• about 2 fold and 3 fold higher at 6 and 15 months of age, respectively
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• about 2 fold higher number of secondary follicles at 15 months of age
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• 88% of ovaries from 17-21 month old females still have large antral follicles with oocytes compared to only 33% of controls
• about 2 fold higher number of antral follicles at 15 months of age
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• impaired regulation of follicle degeneration and apoptosis
• significant reduction of pyknosis in the antral follicles at 6 months of age
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• hypertrophy of uterine tissue at 20 months of age
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• oocytes could be retrieved following superovulation of 15 month old females unlike in age-matched wild-type females
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• significantly prolonged leading to an increase in the duration of the estrous cycle
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• 18% of females are able to get pregnant at 12-16 months of age but are unable to deliver viable pups
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cellular
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• at 17-21 months of age many of the large antral follicles contain unhealthy looking irregular shaped oocytes
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• MEFs are resistant to doxorubicin and H2O2 induced apoptosis
(J:208406)
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• decrease in levels of cleaved caspase-3 in the estrus phase in 2 month old mice
(J:208406)
• significant reduction of pyknosis in the antral follicles at 6 months of age
(J:208406)
• granulosa cells are resistant to TNF induced apoptosis
(J:208406)
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homeostasis/metabolism
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• MEFs are resistant to doxorubicin and H2O2 induced apoptosis
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endocrine/exocrine glands
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• at 20 months of age ovaries contain follicles at various developmental stages and corpora lutea, unlike wild-type females that lack follicles by this age
• many of the aged ovaries display preovulatory-like follicles that are not seen in age-matched wild-type females
|
|
|
• about 2 fold higher at 15 months of age
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• about 2 fold and 3 fold higher at 6 and 15 months of age, respectively
|
|
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• about 2 fold higher number of secondary follicles at 15 months of age
|
|
|
• 88% of ovaries from 17-21 month old females still have large antral follicles with oocytes compared to only 33% of controls
• about 2 fold higher number of antral follicles at 15 months of age
|
|
|
• impaired regulation of follicle degeneration and apoptosis
• significant reduction of pyknosis in the antral follicles at 6 months of age
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