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Phenotypes Associated with This Genotype
Genotype
MGI:5610010
Allelic
Composition		 Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
Igktm2(IGK)Vlcg/Igktm2(IGK)Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2(IGH)Vlcg mutation (0 available); any Igh mutation (41 available)
Igktm2(IGK)Vlcg mutation (0 available); any Igk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:208619 )
• restoring expression of Adam6a and Adam6b restores male fertility

immune system
immune system phenotype ( J:208620 )
N
• normal numbers of B cells, normal lambda/kappa ratios, and secondary lymphoid organs appear similar to controls
• produce humanized antibodies following immunization

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory