About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5608591
Allelic
Composition
Hprt1tm1(CAG-Glra3*)Jcme/Y
Pvalbtm1(cre)Arbr/Pvalb+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Glra3*)Jcme mutation (0 available); any Hprt1 mutation (1280 available)
Pvalbtm1(cre)Arbr mutation (5 available); any Pvalb mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amplitudes of evoked field potentials are reduced in CA1 slices
• the power of gamma oscillations in hippocampal subfield CA1 is reduced
• require a higher concentration of bicuculline methiodide to induce pathological activity
• bidirectional synaptic plasticity is compromised
• could not be elicited

behavior/neurological
N
• performance is similar to controls in discriminative associative learning and memory tests
• in light/dark preference, open field and elevated plus maze tests


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory