Phenotypes Associated with This Genotype

Genotype
MGI:5608590

• Allelic Composition: Hprt1^{tm1(CAG-Glra3*)Jcme}/Y; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:207981 )

♂N • no difference in long term potentiation/depression ratio

increased susceptibility to pharmacologically induced seizures ( J:207981 )

♂ • at 40 and 60 minutes after kainate injection

abnormal nervous system electrophysiology ( J:207981 )

♂ • the power of gamma oscillations in hippocampal subfield CA1 is reduced

♂ • the latency to pathological activity following disinhibition with bicuculline methiodide is shorter compared to controls

♂ • with increased network excitability, gamma oscillation was consistently disrupted by EPSPs in slices

abnormal synaptic glutamate release ( J:207981 )

♂ • increased release

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:207981 )

♂ • at 40 and 60 minutes after kainate injection

abnormal object recognition memory ( J:207981 )

♂ • impaired ability to discriminate familiar and novel objects

abnormal spatial reference memory ( J:207981 )

♂ • impaired in a reward based 8-arm radial maze test (make more errors when only 50% of the arms are baited)

abnormal spatial working memory ( J:207981 )

♂ • impaired in a reward based 8-arm radial maze test (increase in the number of revisiting events across all trials)