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Phenotypes Associated with This Genotype
Genotype
MGI:5607729
Allelic
Composition		 Nlrp3M6Btlr/Nlrp3+
Genetic
Background		 C57BL/6J-Nlrp3M6Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M6Btlr mutation (0 available); any Nlrp3 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:216047 )
• mice bearing this mutation exhibit attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin- (IL-) 1 beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory