Phenotypes Associated with This Genotype

Genotype
MGI:5607628

• Allelic Composition: Abcg5^tm1.1Hobb/Abcg5^tm1.1Hobb; Abcg8^tm1.1Hobb/Abcg8^tm1.1Hobb; Tg(CAG-cre/Esr1*)5Amc/?
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular cholesterol metabolism ( J:215443 )

• levels of sitosterol and campesterol are decreased in gallbladder as compared to controls

digestive/alimentary system

abnormal feces composition ( J:215443 )

♂

increased intestinal phytosterol absorption ( J:215443 )

♂ • fractional absorption of the phytosterols, sitosterol and campesterol, is increased

homeostasis/metabolism

abnormal cellular cholesterol metabolism ( J:215443 )

• levels of sitosterol and campesterol are decreased in gallbladder as compared to controls

increased intestinal phytosterol absorption ( J:215443 )

♂ • fractional absorption of the phytosterols, sitosterol and campesterol, is increased

decreased cholesterol level ( J:215443 )

♀ • decreased cholesterol levels in bile, liver and enterocytes as compared to controls

decreased circulating cholesterol level ( J:215443 )

♀ • decreased levels of circulating cholesterol as compared to controls

abnormal phytosterol level ( J:215443 )

decreased phytosterol level ( J:215443 )

♀ • levels of sitosterol and campesterol are decreased in gallbladder as compared to controls

increased phytosterol level ( J:215443 )

♀ • increased levels of sitosterol and campesterol in liver as compared to controls

♀ • increased levels of phytosterols in enterocytes

increased circulating phytosterol level ( J:215443 )

• mean plasma levels of sitosterol and campesterol are increased by 95-fold and 14-fold respectively, as compared to controls

• D4-sitostanol levels in plasma are increased as compared to controls

• D7-sitosterol levels in plasma are increased as compared to controls

decreased cholesterol efflux ( J:215443 )

♂ • decreased amount of cholesterol is excreted into the feces as compared to controls

♂ • decreased amount of cholesterol is excreted into the bile as compared to controls